Mechanism of Drug-drug Interaction Between Salvianolate Injection and Aspirin
Status:
Unknown status
Trial end date:
2018-10-10
Target enrollment:
Participant gender:
Summary
The combination of anti-platelet medicine treatment and Chinese traditional medicine (TCM)
promoting blood circulation to removing blood stasis is widely used in treatment for
cardiovascular disease. However, the material foundation, effective mechanism and drug-drug
interaction is still not clear. In order to solve the puzzle of rational use of Joint
application by TCM and Western Medicine(WM),investigators conduct a research on mechanism of
drug-drug interaction between salvianolate injection and aspirin based on metabolic enzyme
and PK-PD model. This clinical trial contain three groups, aspirin group, salvianolate
injection group and combination (salvianolate injection+aspirin) group. Investigators collect
blood samples at special time points during post-administration.Investigators have already
find out the Salvianolate's pharmacokinetic characteristics in vivo and establish the
biological sample-testing analysis method in previous research. Depending on these results,
this clinical trial aim to explore the pharmacodynamics-pharmacokinetics(PK-PD)
characteristics of combination with Salvianolate and aspirin through biomarkers, blood
concentration. Finally clarify the TCM and WM material basis and mutual mechanism of drug
interaction and guide reasonable clinical prescription.
Phase:
N/A
Details
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences