Mechanism of Cardiac and Cerebral Function Injury Caused by Intraoperative Limb Ischemia-reperfusion
Status:
Recruiting
Trial end date:
2024-06-30
Target enrollment:
Participant gender:
Summary
As a simple auxiliary tool for lower extremity orthopedic surgery, tourniquet can effectively
reduce intraoperative bleeding and ensure the clarity of the operative field, effectively
shorten the operation time and improve the operation efficiency. The extensive use of
tourniquets in lower extremity surgery will not only cause local paralysis, pain and other
complications, but also bring about postoperative complications such as large drainage volume
and deep vein thrombosis. Recent studies have found that tourniquet induced
ischemia-reperfusion injury not only affects the local tissue structure and function of
skeletal muscle, but also causes reperfusion injury in distant organs (such as heart, lung
and brain). Therefore, improving tourniquet ischemia-reperfusion injury after knee
replacement is of great significance to improve the quality of life of patients during the
perioperative period. Therefore, the aim of this study was to investigate the effects of
dexmedetomidine and tourniquet pretreatment on myocardial injury and brain injury caused by
lower extremity ischemia-reperfusion.