Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this research is to find out how a nasal spray (fluticasone furoate),
sometimes given to children with obstructive sleep apnea syndrome (OSAS), works on certain
cells within a child's adenoids. We hypothesize that intranasal steroids lead to an
upregulation of T regulatory cells in the adenoid tissues of children with OSAS. This will
result in a local reduction in inflammation and edema explaining the improvement in OSAS.