Mechanism and Early Intervention Research on ALI During Emergence Surgery of Acute Stanford A Aortic Dissection
Status:
Unknown status
Trial end date:
2015-01-01
Target enrollment:
Participant gender:
Summary
The morbidity rate of Stanford A type Acute Aortic Dissection（AAD） has been increasing, about
5-10/100,000* per year. Emergency surgery has been the main treatment for Acute Aortic
Dissection, however perioperative mortality rate can be as high as 15~30%. Acute lung injury
(ALI) is one of the main complications that happen during the perioperative period, which by
itself covers 30%-50% of the overall mortality rate. Both domestic and foreign countries lack
researches on risk factors, pathogenesis, disease progression and outcome of ALI, which
happen during the perioperative period of Acute Aortic Dissection patients.
This topic study follow projects in the preoperative of Acute Aortic Dissection'surgery
1. hemodynamic changes (aortic dissection resulting in acute aortic regurgitation, cardiac
tamponade and proximal high blood pressure)
2. ischemia - reperfusion injury of aortic dissection distal organ
3. Aortic intima-media exposure cause coagulation / fibrinolytic system function disorder
4. systemic inflammatory response syndrome; use relevant clinical radiographic parameters,
indicators of respiratory mechanics (oxygenation index and lung injury index) and
biochemical indicators.
To discuss risk factors and possible mechanisms of ADD patients with pre-operative ALI and
observe their influences on the progress and prognosis of AAD, to explore early intervention
in the preoperative for possible risk factors and mechanisms and to evaluate their influences
on the prognosis, to achieve the purpose of reducing AAD perioperative mortality of ALI and
medical expenses.