Measurement of the Second Gas Effect on Sevoflurane in Anaesthetised Patients

• Status: Completed
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is investigating the "second gas effect", a phenomenon produced by the uptake of nitrous oxide (N2O) by the lungs, during the course of a typical anaesthetic. The effect is to increase the concentration of other breathed gases in the lung. These include oxygen and volatile anaesthetic agents such as sevoflurane, which are also normally administered along with N2O. We wish to i) measure the magnitude of the second gas effects on both blood and expired concentrations of sevoflurane (Part 1), and ii) see if a demonstrable difference exists between the effects on blood and expired concentrations.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Austin Health
• Treatments: Nitrous Oxide; Sevoflurane

Criteria

Inclusion Criteria:

• Patients scheduled for elective surgery requiring relaxant general anaesthesia with arterial blood pressure monitoring via an arterial line.

Exclusion criteria:

• Patients with moderately or severely impaired respiratory disease (FEV1 < 1.5L, or FVC < 2.0L).

• Patients under 18 years of age.

• Morbidly obese patients: BMI > 30

• Patients unable to give informed consent.