Measurement of Risperidone and 9-Hydroxyrisperidone in Plasma and Saliva
Status:
Completed
Trial end date:
2003-04-01
Target enrollment:
Participant gender:
Summary
The purpose of this research is to: (1) examine the secrection of risperidone (RIS)
(Risperdal) and its metabolite, 9-OH-RIS, in saliva, (2) determine the concentration ratio of
RIS and 9-OH-RIS between plasma and saliva, and (3) compare the rate of decline in
concentration of RIS and 9-OH-RIS in saliva and plasma by measurements at timed intervals
during a single dosing interval.