Measurement of Glucose Metabolism in Humans Using Magnetic Resonance at 4 Tesla. Substudy: Hypoglycemia Unawareness

• Status: Completed
• Trial end date: 2017-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether islet transplantation alters brain glucose concentrations in patients with type 1 diabetes, recurrent hypoglycemia, and hypoglycemia unawareness when compared to that measured prior to transplant in the same subjects.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Treatments: Somatostatin

Criteria

Inclusion Criteria:

• Age 18-65

• Must be able to provide informed consent

• Type 1 diabetes >5 years duration

• Healthy controls

Exclusion Criteria:

• Over 300 pounds

• Claustrophobic

• History of ischemic heart disease, arrhythmia or seizure disorder

• Pregnant

• On medications known to alter blood flow or carbohydrate metabolism

• Have internally located pieces of metal