Mast Cells in Acid-induced Intestinal Permeability
Status:
Unknown status
Trial end date:
2017-02-01
Target enrollment:
Participant gender:
Summary
This is a randomized, double-blind, cross-over study in healthy volunteers. In the first
part, the duodenum of the participants will be perfused with acid or saline, during which
intragastric pressure will be monitored to assess activation of the duodenogastric reflex.
After perfusion, duodenal biopsies will be collected to evaluate mucosal integrity. In the
second part, healthy volunteers are treated with the mast cell stabilizer disodium
cromoglycate or with a placebo during 14 days. Subsequently, the duodenum will be perfused
with acid and intragastric pressure and mucosal integrity will be evaluated.