Mass Spectrometry Based Cutoffs for Cortisol After Stimulation Tests
Status:
Unknown status
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
There are two main stimulation tests used to decide if a patient has cortisol deficiency. It
is the "synacthen test", were we stimulate the patient with intramuscular or intravenous
synacthen ( ACTH) to see how much cortisol the adrenals are capable of producing, and it is
the "Insulin hypoglycemia test" were we give the patient insulin to provoke a hypoglycemia,
and look at the adrenal response to that stimulus. The cut off values for a normal response
is based on old immunological assays no longer in use. Assays with a lot of interference and
cross reactivity leading to measurement of higher values for cortisol than what we measure on
the highly specific LCMS/MS ( Liquid chromatography mass spectrometry methode) that we are
using for cortisol today. So, there is a need for new cut off values for a normal response to
such tests. The purpose of this study is to produce such new cutoff values by performing the
test in 120 healthy controls. We also want to perform the test in patient groups normally
going trough this tests according to the same protocol as the control persons, to evaluate
the new cutoffs in different patient groups.