Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol

• Status: Completed
• Trial end date: 2012-04-01
• Target enrollment: 0
• Participant gender: Female

Summary

Anesthesia may affect the function of vital organs. Liver is one of them. The investigator's hypothesis is that intravenous or inhalation anesthesia does not impair liver function as assessed by more elegant tests like markers indicating liver apoptosis. In the present randomized prospective trial female patients scheduled for mastectomy or thyroidectomy will receive inhalation or total intravenous anesthesia and markers for liver dysfunction will be determined.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Athens
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Female patients aged between 30 and 65 years old scheduled for thyroidectomy or breast surgery for cancer

Exclusion Criteria:

• Drug intake which may affect liver function

• Severe cardiovascular or respiratory disease

• Hepatic or renal dysfunction

• Pregnancy

• Alcohol and drug abuse

• Body Mass Index (BMI) > 35