Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
Status:
Completed
Trial end date:
2019-01-10
Target enrollment:
Participant gender:
Summary
This study will examine the hypothesis that changes in the cognition (i.e. thinking and
memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers
Disease in the fluid around the brain and spinal cord (i.e. cerebrospinal fluid, or CSF),
and/or changes in brain connectivity. The investigators will also examine whether different
types of anesthesia have different effects on these CSF markers of Alzheimers disease, or
different effects on thinking and memory after anesthesia and surgery, or differential
effects on the correlation between cognitive changes and CSF marker changes.