Mapping Draining Lymph Nodes in CNS Malignancies

• Status: Recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to determine whether the lymph nodes that drain a brain tumor can be detected by imaging after injection of a substance called Tc-99m tilmanocept directly into the brain tissue around the tumor. Tc-99m tilmanocept is a radioactive substance that is used to find lymph nodes by injecting it and then scanning the body with a device that can trace its radioactivity. In this study, the investigators are looking to see how long it takes the Tc-99m tilmanocept to travel from the tumor to the lymph nodes. The investigators will be using it to map lymph nodes as they relate to specific brain areas.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Washington University School of Medicine
• Collaborator: Lloyd J. Old STAR Program

Criteria

Inclusion Criteria:

• Candidate for surgical resection of suspected brain tumor, including benign tumors (e.g., meningioma) and malignant tumors (e.g., glioma or metastatic disease).

• Suitable candidate to receive TC 99m injection and study related imaging post-op per the PI and/or treating neurosurgeon.

• At least 18 years of age.

• Willing and able to provide informed consent (or consent of legally authorized representative).

Exclusion Criteria:

• Documented hypersensitivity to dextran and/or modified forms of dextran.

• Pregnant.

• Prior surgical evacuation of lymph nodes of the head and/or neck