Mannitol vs HS to Treat ICHT After Severe TBI : Comparison on PtiO2 and Microdialysis Values

• Status: Terminated
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether hypertonic saline is as much effective as mannitol to treat intracranial hypertension after traumatic brain injury and has at least the same effects on PtiO2 and cerebral metabolism studied through microdialysis.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Direction Centrale du Service de Santé des Armées
• Treatments: Mannitol

Criteria

Inclusion Criteria:

• Severe Traumatic brain injury monitored with ICP, PtiO2 and cerebral microdialysis

• And ICP> 20 mm Hg needing osmotherapy

• And approval of the next of kind

Exclusion Criteria:

• Bilateral fixed dilated pupils

• Contra-indication to multimodal neuromonitoring

• Previous CNS disease

• Contra-indication to HS (cardiac insufficiency,...)

• Natremia > 155 mmol/L or osmolarity > 320 mOsm/L