Mannitol Versus Supportive Care in Ciguatera Fish Poisoning
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Ciguatera poisoning, caused by the ingestion of ciguatoxin-containing fish, is a global
public health concern. In the US, the vast majority of ciguatera poisonings occur in Florida,
followed by Hawaii and California. Equipoise exists in the medical literature regarding the
effectiveness of mannitol therapy in treatment of ciguatera poisoning. While there are many
case reports attesting to its utility, the only randomized control trial (RCT) comparing
mannitol therapy with supportive care failed to show any significant benefit from mannitol
treatment for a variety of clinical outcomes. Investigators therefore propose a second,
larger RCT to test this question.