Mannitol-Induced Cough Challenge in Healthy Controls and Subjects With Mild Allergic Asthma
Status:
Completed
Trial end date:
2020-01-31
Target enrollment:
Participant gender:
Summary
The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke
coughing reproducibly in mild allergic asthmatics compared with healthy controls and if
salbutamol can affect this. Phase 1 of this study is a reproducibility analysis of cough dose
response to mannitol in a cohort of mild allergic asthmatics and healthy controls. Phase 2 is
a double-blind, placebo-controlled analysis in mild allergic asthmatics assessing the effects
of salbutamol on mannitol induced cough.