This is an ancillary study conducted as part of the BASALT trial [NCT00495157].
The overall hypotheses are: 1) an indirect airway challenge procedure using mannitol can
safely characterize asthma phenotypes, predict asthma control and exacerbations, predict
responses to interventions, and perform more specifically than a direct methacholine
challenge and; 2) PX27 pore function in whole blood correlates with measures of airway
hyperresponsiveness induced by methacholine and/or mannitol challenges
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Wisconsin, Madison
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI) Pharmaxis