Manipulating the Microbiome in IBD by Antibiotics and FMT
Status:
Completed
Trial end date:
2021-01-01
Target enrollment:
Participant gender:
Summary
the etiology of Inflammatory Bowel Diseases (IBD) is closely associated with the gut
microbiome. The results of previous studies on the effectiveness of antibiotics and fecal
macrobiota transplantation (FMT) are contradicting.
Aims: to evaluate the effectiveness of wide-spectrum antibiotic regimens in acute severe
colitis in an addition to standard corticosteroid therapy (UC and isolated "UC-like" Crohn's
colitis). The secondary aim is to assess the outcome of FMT in those not responding to five
days of therapy (in either arm). As an exploratory aim, any IBD patient with a resistant
disease to at least two immunosuppressive medications, may be treated with either
interventions.