Mandibular Furcation III Regeneration (FURC-III-REGEN)

• Status: Recruiting
• Trial end date: 2027-06-15
• Target enrollment: 0
• Participant gender: All

Summary

Teeth with furcation grade III defects will be treated with open flap debridement and regenerative therapy with biphasic calcium phosphate combined with either enamel matrix proteins or a collagen membrane.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Oslo
• Treatments: Calcium; Calcium, Dietary

Criteria

Inclusion Criteria:

• Subject must be ≥ 20 years

• Subject must have periodontal disease as determined by the World Workshop 2017 criteria

• Subjects must be undergoing periodontal treatment or follow-up and present 1 or more pair of bilateral mandibular molars affected by furcation involvement grade II with PPD >4 mm, and the furcation fornix must be below a tangential line from the distal to mesial interproximal crestal bone level

• Competent to give consent

Exclusion Criteria:

The following must not be present at the time of enrolment;

• Previous radiotherapy to the jaws, current use of chemotherapy, systemic long-term corticosteroid treatment

• Present or past use of bisphosphonate treatment

• Pregnant or nursing subjects

• Patients classified as > class 2 according to the ASA (American Society of Anesthesiologists) physical status classification

• Previous surgical therapy of included furcation defects

• Inability to comprehend and respond to the quality of life questionnaire

• Dental restorations or prosthesis involving the furcation area

• Root fractures or suspected infractions

• Caries lesions in the furcation area

• No systemic antibiotic treatment within 3 months prior to intervention