Management of Mandibular ORN: PENTO as Medical Treatment
Status:
Completed
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
Mandibular osteoradionecrosis, despite its low incidence, remains being the most problematic
and irreversible complication after head and neck radiotherapy with no medical treatment to
limit or reduce symptoms.
Different clinical trials have shown a significant scientific evidence that the treatment
with pentoxifylline + tocopherol achieves a certain effectiveness in the treatment of the
tissue fibrosis. This study proposes to use this drugs to determine if there is healing of
mandibular osteoradionecrosis and/or a symptomatic improvement as well.
Phase:
Phase 4
Details
Lead Sponsor:
Hospital Vall d'Hebron
Treatments:
alpha-Tocopherol Pentoxifylline Tocopherols Tocotrienols Vitamin E