Overview

Malarone Pharmacokinetics Under Simulated Physiologic Stressors of Deployment

Status:
Withdrawn
Trial end date:
2021-05-23
Target enrollment:
Participant gender:
Summary
A 2x2 randomized crossover of single dose malarone at rest and during moderate intensity exercise under controlled conditions of heat and humidity in healthy adult participants. Statistical analysis of AUC and Cmax will be performed to determine pharmacokinetic changes.
Phase:
Phase 4
Details
Lead Sponsor:
Walter Reed Army Institute of Research (WRAIR)
Treatments:
Atovaquone, proguanil drug combination