Overview

Maintenance Treatment of Apatinib in Nasopharyngeal Carcinoma

Status:
Unknown status
Trial end date:
2019-12-08
Target enrollment:
0
Participant gender:
All
Summary
The study is to evaluate the efficacy and safety of Apatinib for later treatment of patients(after second-line treatment for locally recurrent or metastatic nasopharyngeal carcinoma), including overall survival (OS), distant metastasis-free survival (DMFS) and locoregional relapse-free survival (LRRFS); the relationship between EBV DNA copy number and survival after radiotherapy or radiochemotherapy; Quality of life score (QoL); evaluation of drug safety.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Guilin Medical University, China
Collaborators:
Guangxi Naxishan Hospital
National Hospital of Guangxi Zhuang Autonomous Region
Wuzhou Red Cross Hospital
Treatments:
Apatinib
Criteria
Inclusion Criteria:

1. Male and female patients aged ranging from 18 to 70 years old.

2. Patients with newly histologically proven nasopharyngeal carcinoma (NPC).

3. Local recurrent NPC patients after comprehensive treatment, including clinical
examination found a clear local area residue: electronic nasopharyngoscope found clear
residual or enlarged cervical lymph nodes.

4. Distant metastatic NPC patients after comprehensive treatment, including liver B
ultrasound, chest X-ray, bone scan or other clinicians consider appropriate tests such
as CT, MRI or PET/CT found distant metastases.

5. Comprehensive treatment of local recurrence or distant metastasis after line or
second-line therapy found progressive disease.

6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1.

7. Patient who has the expected survival time more than 3 months.

8. Adequate hematological function: hemoglobin >80 g/L (no transfusion within 14 days),
neutrophil count > 1.5×109/L, platelet count 80×109/L.

9. Adequate liver function (serum total bilirubin ≤ 1.5 mg/dL, serum transminase ≤ 2.5
times higher than upper limit).

10. Adequate renal function (creatinine clearance ≥ 50 mL/min).

11. Participants volunteered to participate in this study, signed informed consent, good
compliance and cooperated with us to complete the follow-up.

Exclusion Criteria:

1. Before treatment, MRI showed that the tumor might be an important risk factor (for
example, wrapping around the internal carotid artery / vein); or researchers judged
that the tumor is a high risk of serious blood vessel bleeding during the treatment.

2. Patient who has serious hemorrhages, any serious bleeding events classification at 3
degree or more (according to CTCAE4.0) within the last 4 weeks.

3. Patient who has high blood pressure can not be controlled by a single antihypertensive
drug treatment (Systolic pressure > 140 mmHg, diastolic pressure > 90 mmHg); any
unstable angina pectoris; with a history of angina pectoris were newly diagnosed with
angina pectoris within 3 months before screening; any myocardial infarction events
occurred within 6 months before screening; arrhythmia (including QTcF: male ≥ 450ms,
female ≥ 470 ms) need long time use of antiarrhythmic drugs and heart function
insufficiency ≥II according to New York Heart Association class.

4. Patient who has positive urine protein.

5. Patient who has abnormal coagulation and bleeding tendency (signed informed consent
before 14 days, and must be satisfied: INR is in the normal range without the use of
anticoagulants); Application of anticoagulants or vitamin K antagonists such as Hua
Falin, heparin or its analogues, with international normalized ratio (INR) is less
than 1.5, allows the use of small dose Hua Falin (1 mg orally, once daily) or small
dose aspirin (total dose ≤ 100 mg daily).

6. Medical history of arteriovenous thrombosis event within the past year, such as
cerebral vascular accident (including transient ischemic attack) and deep venous
thrombosis (venous catheter thrombosis caused by chemotherapy and investigator judged
that the patient had recovered, these patients should be except) and pulmonary
embolism.

7. A healed wound for long time or incomplete fracture.

8. Any factors that affect the oral drug, such as the inability to swallow, diarrhea and
intestinal obstruction.

9. For females: patients should be surgical sterilization or postmenopausal patients, or
willing to receive a medical approved contraception during treatment and 6 months
after the end of the treatment; serum or urine pregnancy test must be negative, and
must be non lactating period within 7 days before study; for males: patients should be
treated with surgical sterilization or willing to receive a medical approved
contraception during treatment and 6 months after the end of the treatment.

10. History of psychotropic substance abuse and can not be removed or psychiatric
disorders.

11. Medical history of immunodeficiency, or other acquired, congenital immunodeficiency
disease, or history of organ transplantation.

12. Any serious harm to the subject's safety or evidence of significant medical illness
that in the investigator's judgment will substantially increase the risk associated
with the subject's participation in and completion of the study.