Hyponatraemia arises in between 20% and 45% of sick hospitalized children. An important
reason for this high incidence could be use of hypotonic fluids in sick children for
maintenance fluid therapy. There are no randomized controlled trials to evaluate the effect
of various types of intravenous fluids on the incidence of hyponatremia in sick hospitalized
children.
Hypothesis: Use of normal saline in 5% dextrose or reduced (2/3) volume of N/5 saline in 5%
dextrose reduces incidence of hyponatremia (serum sodium 130 mmol/L) by two-thirds when
compared to N/5 saline in 5% dextrose at standard maintenance rate in hospitalized children
receiving intravenous maintenance fluids.
Phase:
Phase 3
Details
Lead Sponsor:
All India Institute of Medical Sciences, New Delhi