Magnetic Resonance Imaging of Aortic Aneurysm Instability

• Status: Completed
• Trial end date: 2010-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Abdominal aortic aneurysm (AAA) is a progressive enlargement of the aorta, the largest blood vessel in the body. It is at risk of bursting when it is usually fatal. Currently the risk of the AAA bursting is estimated from its diameter. In this study, the investigators hope to develop a new type of aneurysm scan involving Magnetic Resonance Imaging (MRI). It is hoped that this scan will be better at determining which AAAs are at risk of bursting and therefore require an operation to prevent this.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Edinburgh
• Collaborator: British Heart Foundation

Criteria

Inclusion Criteria:

• AAA measuring >40mm in AP diameter on ultrasound scanning

• Age >40 years (patients younger than this with AAA may have a connective tissue disorder and a different aetiology to their disease)

• Considered to be suitable for standard infra-renal open surgical repair

Exclusion Criteria:

• Patients who are not deemed to be fit for open surgical repair

• Patients who are deemed to be suitable for a stent graft performed by the radiologists rather than the standard operation

• Contraindication to MRI scanning identified from MRI Safety Questionnaire (see attached)or claustrophobia

• Age <40 years

• Patients requiring emergent repair such that there is insufficient time available to complete the protocol

• Patients refusing to give consent

• Patients unable to give consent

• Pregnant women (contrast is teratogenic in animals)

• Intercurrent illness (may confound the results)

• Patients with a systemic inflammatory disorder or underlying malignancy

• Patients who require an emergency operation such that there is insufficient time to complete the study protocol

• Renal dysfunction (Creat >250 or eGFR<25)

• Hepatic dysfunction (Child's grade B or C)