Magnetic Resonance Imaging for Lymph Node Staging in Ovarian Cancer
Status:
Withdrawn
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
Advanced epithelial ovarian cancer has high morbidity and mortality. Patients presenting with
advanced stage ovarian cancer often have cancer spread to regional lymph nodes. Imaging
strategies to depict involved lymph nodes are currently not successful. The purpose of this
study is to evaluate if magnetic resonance imaging (MRI) with gadofosveset trisodium contrast
enhancement (GDF-MRI) and diffusion weighted imaging (DW-MRI) is able to identify involved
lymph nodes in a preoperative setting. This could guide the surgeon during surgery to dissect
lymph nodes which could lead to an optimal diagnosis/staging with the lowest possible
morbidity. We want to determine the optimal imaging settings and feasibility of MRI for the
detection of pathological lymph nodes in women with advanced (FIGO stage IIB-IV) ovarian
cancer undergoing primary debulking surgery and compare this to conventional imaging with
computer tomography (CT).