Magnetic Resonance Imaging Study of Cognitive-Behavior Therapy for Major Depressive Disorder

• Status: Unknown status
• Trial end date: 2015-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Study hypothesis: psychotherapy and SSRI treatment effect in different brain way:

psychotherapy in "up to down" way and SSRI in "down to up" way. The investigators will explore this hypothesis in major depressive disorder outpatients with Magnetic Resonance Imaging analysis in this study. Patients in different groups will be treated by psychotherapy or SSRI treatment. They will all be checked with Magnetic Resonance Imaging pro and after 12 weeks of treatment.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Nanjing Medical University
• Treatments: Antidepressive Agents; Citalopram; Dexetimide; Fluoxetine; Fluvoxamine; Paroxetine; Sertraline

Criteria

Inclusion Criteria:

• meet SCID -Ⅰ/P major depressive disorder diagnosis;

• Right handedness;

• good visual acuity.

Exclusion Criteria:

• neurological disease ;

• serious physical illness (e.g. heart, lung, liver, kidney or blood system disease);

• with other mental disorder;

• psychotic symptoms

• personality disorders;

• pregnancy;

• suicidal risk;

• treatment by antidepressants or other psychotropic medications within 6 months prior to the start of the trial;

• with contraindication for MRI