Magnesium for Peroral Endoscopic Myotomy

• Status: Recruiting
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will reduce the incidence of postoperative pain while decreasing perioperative opioid requirements.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Treatments: Magnesium Sulfate

Criteria

Inclusion Criteria:

• Planned peroral endoscopic myotomy procedure

Exclusion Criteria:

• cannot give consent

• patients who are clinically unstable and/or require urgent/emergent intervention

• previous esophageal myotomy

• preexisting hypermagnesemia

• end-stage renal disease

• neuromuscular disease, including but not limited to Guillain-Barre syndrome, myasthenia gravis, congenital myopathy, and muscular dystrophy

• preexisting heart failure

• severe ventricular systolic dysfunction (left or right ventricle)