Breast cancer is the most diagnosed type of cancer in women in Turkey and in the world.
According to the World Health Organization data, the rate of newly diagnosed breast cancer
was reported as 11.6% in 20181. Acute postoperative pain occurs in 40% of patients undergoing
surgery for breast cancer2. In the early postoperative period, opioids are commonly used
analgesics in the treatment of pain, but they have various side effects such as
gastrointestinal, urinary and respiratory symptoms3. Non-opioid analgesics can be used to
reduce opioid use and thus limit its side effects. Magnesium sulfate (MgSO4) is an N-Methyl
D-Aspartate (NMDA) receptor antagonist that has been used for postoperative analgesia and
reducing both the duration and intensity of pain by preventing central sensitization in
response to peripheral painful stimulus4-9. The primary aim of this study is to investigate
the postoperative analgesic efficacy of MgSO4 in patients who were scheduled for mastectomy
with the diagnosis of breast cancer. The secondary aim of our study is to evaluate the
changes in perioperative vital signs that may occur due to MgSO4.