Overview

Magnesium Sulfate in Adductor Canal Blocks

Status:
Completed
Trial end date:
2017-02-01
Target enrollment:
0
Participant gender:
All
Summary
Proper analgesia after total knee arthroplasty (TKA) is important for encouraging early ambulation, which can facilitate improved patient outcomes and early hospital discharge. For pain control after TKA, adductor canal blocks (ACBs) improve upon the gold standard femoral nerve blocks (FNBs) since they do not cause as much quadriceps muscle weakening, while providing equivalent analgesia. Multimodal analgesia has become commonplace as a method of superior pain control with fewer side effects. Magnesium sulfate as an adjuvant to FNB local anesthetics can improve pain control after surgery; however, it also prolongs time to ambulation. There are no reports on the effect of magnesium sulfate in ACBs on analgesia after TKA. Thus the purpose of this randomized, double-blind, controlled trial is to determine whether magnesium sulfate given with local anesthetics via ACB can prolong analgesia, reduce pain scores and opioid consumption, and increase mobilization in TKA patients.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Queen's University
Treatments:
Magnesium Sulfate
Ropivacaine
Criteria
Inclusion Criteria:

- American Society of Anesthesiologists classification score of 1 to 3

- Presenting for unilateral primary total knee arthroplasty

- age 18 to 85

Exclusion Criteria:

- inability to use a patient-controlled analgesia pump

- long-standing use of opioid medications (3 months or longer)

- history of chronic pain syndromes

- significant cardiovascular disease

- medical conditions that preclude the use of a regional anesthetic technique or any of
the study drugs

- inability to read and understand English

- incompetent to give consent to study participation

- women who are pregnant or nursing