Overview

Magnesium Sulfate as Adjuvant Analgesia and Its Effect on Opiate Use of Post-operative Transplant Patients in the Pediatric ICU

Status:
Recruiting
Trial end date:
2023-08-01
Target enrollment:
0
Participant gender:
All
Summary
To use magnesium sulfate as adjuvant analgesia by implementing a treatment protocol in order to determine whether can benefit pediatric pain in post-operative transplanted patients and decrease overall opioid consumption.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Minnesota
Treatments:
Magnesium Sulfate
Criteria
Inclusion Criteria:

Experimental Group:

- Be scheduled for and receive a liver transplant or total pancreatectomy and islet cell
autotransplantation

Control Group:

- Received a liver transplant or total pancreatectomy and islet cell autotransplantation.

Exclusion Criteria:

Experimental Group:

- Pregnant or unwilling to abstain from sex if not practicing birth control during
participation in the study.

- Presence of a condition or abnormality that in the opinion of the Investigator would
compromise the safety of the patient or the quality of the data.

- Known allergic reactions to components of the MgSO4

- History of heart block or myasthenia graves in past medical history.

- Presence of cardiac pacemaker

- Any patient with preoperative creatinine level > 1.5x upper limit of normal.

Control Group:

- Any patient who had filed as research-exempt (opt-out of research previously).

- Any patient with preoperative creatinine level > 1.5x upper limit of normal.