Magnesium Sulfate Versus Ipratropuim Bromide in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• Status: Completed
• Trial end date: 2007-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Treatment with short acting β2 agonists for exacerbations of COPD results in clinical improvement. It has not been established whether combining short acting β2 agonists to other bronchodilators is more effective than β2 agonists alone. The aim of this study is to evaluate the efficacy and safety of combination of SABA and MgSO4 in comparison to SABA and ipratropium bromide (IB) in patients attending the emergency department for AECOPD.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Bromides; Ipratropium; Magnesium Sulfate; Terbutaline

Criteria

Inclusion Criteria:

• 40 years old or over

• have known or suspected COPD based on pulmonary function test, arterial blood gas, clinical history, physical examination, and chest radiograph

• worsening of dyspnea within 2 weeks,

• partial pressure of arterial carbon dioxide (PaCO2) >45 mmHg

• respiratory rate >24/min

• arterial pH <7.35

• partial pressure of arterial oxygen (PaO2) <50 mmHg under room air

Exclusion Criteria:

• hypersensitivity to anticholinergics and to magnesium sulfate

• patients that received anticholinergics within 6 hours before ED admission

• systolic arterial pressure <90 mmHg or need to vasoactive drugs