Magnesium Loading in Chronic Obstructive Pulmonary Disease
Status:
Completed
Trial end date:
2007-11-01
Target enrollment:
Participant gender:
Summary
Dietary magnesium (Mg) intake has been shown to be independently related to lung function,
airway reactivity, and respiratory symptoms in the general population. Inhaled Mg and IV Mg
administration have been shown to promote bronchodilation and to improve lung function in
asthmatic patients. Some studies have suggested that COPD patients exhibit decreased body
levels of Mg. The purpose of the present study was to investigate the effects of acute IV Mg
loading on parameters of respiratory function and maximal exercise capacity of stable COPD
patients.The study hypothesis is that Mg administration will be associated to improvements on
airflow and vasodilation leading to improvements of pulmonary function and exercise
performance.