Overview

Macrolide Azithromycin to Prevent Rapid Worsening of Symptoms Associated With Chronic Obstructive Pulmonary Disease

Status:
Completed
Trial end date:
2010-07-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to determine if long-term administration of a macrolide antibiotic will reduce worsening of symptoms among individuals with chronic obstructive pulmonary disease (COPD).
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Minnesota
University of Minnesota - Clinical and Translational Science Institute
Collaborator:
National Heart, Lung, and Blood Institute (NHLBI)
Treatments:
Anti-Bacterial Agents
Antibiotics, Antitubercular
Azithromycin
Criteria
Inclusion Criteria:

- Clinical diagnosis of at least moderate Chronic Obstructive Pulmonary Disease (COPD),
as defined by the following Global Initiative for COPD (GOLD) criteria:

1. Post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital
capacity (FVC) ratio of less than 70%

2. Post-bronchodilator FEV1 less than 80% predicted, with or without chronic
symptoms

- Cigarette consumption of 10 pack-years or more (may or may not be active smokers)

- Meets one or more of the following four conditions:

1. Current, or history of, supplemental O2 use

2. Received a course of systemic corticosteroids for respiratory problems within 1
year prior to study entry

3. Visited an emergency department for a COPD exacerbation within 1 year prior to
study entry

4. Hospitalized for a COPD exacerbation within 1 year prior to study entry

- Willing to make return visits

- Available by telephone for duration of study

- Minimum of 4 weeks from the most recent acute exacerbation (have not received a course
of systemic corticosteroids, an increased dose of chronically administered systemic
corticosteroids, and/or antibiotics for an acute exacerbation for a minimum of 4 weeks
from the time of study entry)

Exclusion Criteria:

- Diagnosis of asthma

- Diagnosis other than COPD that results in the patient being either medically unstable,
or having a predicted life expectancy less than 3 years

- Special patient groups (i.e., prisoners, pregnant women, or institutionalized
patients)

- Women who are at risk of becoming pregnant during the study (pre-menopausal) and who
refuse to use acceptable birth control (i.e., hormone-based oral or barrier
contraceptive) for the duration of the study

- History of hypersensitivity to any macrolide antibiotic

- Taking any of the following medications:

1. Cisapride

2. Ergot derivatives

3. Pimozide

4. Disopyramide

5. Cyclosporin

6. Tacrolimus

7. Nelfinavir

8. Bromocriptine

9. Hexobarbital

- Corrected QT interval (QTc) on electrocardiogram exceeding 440 ms

- Taking rifabutin or rifampin

- Chronic hepatic insufficiency

- Chronic renal insufficiency

- Diagnosis of bronchiectasis (defined as production of greater than one-half cup of
purulent sputum/day)

- If, for either ear, formal audiometric testing in a sound booth results in a pure tone
average (i.e., the average of the thresholds for the 4 frequencies 1000, 2000, 3000,
or 4000) exceeding 50 decibel (dB), or if the threshold at any one frequency exceeds
60 dB, then the participant will be counseled by the audiologist concerning hearing
aids and/or referral to an otolaryngologist. In addition, the audiologist may discuss
with the participant whether or not to continue in the study. Following the
examination and counseling, the participant will also discuss whether or not to
continue in the study with one of the study investigators. If it is found that a
participant's pure tone average in the two ears differs by more than 15 dB, or if the
difference in the two ears for any one frequency exceeds 20 dB, then the participant
will not be eligible for randomization into the study unless cleared by an
otolaryngologist