MTZ Plus AMX in the Treatment of Smokers and Non-smokers
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Randomized controlled clinical trials have demonstrated that the use of amoxicillin (AMX) and
metronidazole (MTZ) as adjuncts to mechanical therapy improves the clinical and
microbiological outcomes of scaling and root planing (SRP) in non-smokers and smokers with
ChP. However, the effects of this antibiotic protocol have not been directly compared in
non-smokers and smokers. Therefore, the aim of this study will be to compare the clinical and
microbiological effects of the adjunctive use of MTZ+AMX to SRP in smokers and non-smokers
subjects with chronic periodontitis (ChP). It was hypothesized that non-smokers would benefit
better from this combination of therapies than the smokers.