MRI-visible Enlarged Perivascular Spaces and the Alteration of Lymphatic Drainage System in CAA
Status:
Recruiting
Trial end date:
2023-07-31
Target enrollment:
Participant gender:
Summary
In this three-year proposal, we will explore the MRI-visible EPVS in CAA and investigate its
pathophysiology using animal models. Our specific aims include: (1) Establish the
relationship of MRI-visible enlarged perivascular space and CAA, (2) Determine whether
vascular amyloid clearance in CAA is associated with lymphatic drainage system, (3) Establish
longitudinal data for MRI-visible enlarged perivascular space and cerebral amyloid angiopathy
progression.