MRI of Glymphatic Clearance During Anesthetic Sedation

• Status: Completed
• Trial end date: 2017-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5 healthy human subjects as visualized by diffusion tensor MRI. The study is designed to measure clinically established, safe imaging of DTI and cerebral blood flow at baseline, during a continuous intravenous infusion of dexmedetomidine at doses designed to produce anesthesia-induced unconsciousness to simulate natural sleep, and again on return to wakefulness.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pennsylvania
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

1. Person aged 20-40 years old,

2. American Society of Anesthesiologists Physical Status I or II (i.e., healthy),

3. Body mass index ≤ 30 kg/m2,

4. Easily visualized uvula,

5. Not a current tobacco user

6. No history of alcohol abuse/must abstain from alcohol use 24 hours prior to and 24 hours after participation.

7. Ability to sign informed consent.

8. Able to pass standard MRI safety screening

9. Must have a responsible adult available to transport subject home safely after end of experiment.

Exclusion Criteria:

1. Healthy male or females less than 20 years of age or older than 40 years of age

2. Any physical signs suggestive of difficult airway (mouth opening 3cm, short distance between the chin and neck, poor mandibular subluxation, thick neck),

3. History of obstructive sleep apnea,

4. History of asthma

5. Neuropsychiatric disorders,

6. History of, or current use of psychotropic medications,

7. Current tobacco use or history of smoking in past month

8. Alcohol use exceeding 2 drinks/day

9. History of hypertension or current medication for blood pressure control,

10. Cardiovascular disease or arrhythmias,

11. Positive urine toxicology screen,

12. History of gastroesophageal reflux disease,

13. Pregnancy,

14. Sleep disorders,

15. History of postoperative nausea/vomiting or motion sickness,

16. Inability to sign informed consent

17. Contraindications for safely participating in MRI imaging study,

18. Does not have a responsible adult available to provide transport from HUP MRI area to home.