MRI of Glymphatic Clearance During Anesthetic Sedation
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
This study is to assess the effect of dexmedetomidine anesthesia on glymphatic flow in 5
healthy human subjects as visualized by diffusion tensor MRI. The study is designed to
measure clinically established, safe imaging of DTI and cerebral blood flow at baseline,
during a continuous intravenous infusion of dexmedetomidine at doses designed to produce
anesthesia-induced unconsciousness to simulate natural sleep, and again on return to
wakefulness.