MRI-Guided Laser Surgery and Doxorubicin Hydrochloride in Treating Patients With Recurrent Glioblastoma Multiforme
Status:
Completed
Trial end date:
2018-05-30
Target enrollment:
Participant gender:
Summary
This pilot clinical trial studies magnetic resonance imaging (MRI)-guided laser surgery (MLA)
and doxorubicin hydrochloride in treating patients with recurrent glioblastoma multiforme.
The blood brain barrier (BBB) is a separation of circulating blood from the tissue of the
central nervous system, preventing substances in the blood from entering the brain. MLA
disrupts the BBB around the tumor which may allow cancer-killing substances to be carried
directly to the tumor and the surrounding area. Using MLA prior to chemotherapy may result in
a greater concentration of drug in the tumor to kill the cancer cells while limiting side
effects.