Lysine specific demethylase-1 (LSD1) is an epigenetic regulator of gene transcription
involved in the pathophysiology of elevated blood pressure and likely renal damage in Blacks.
This project investigates whether a genetically driven anti-hypertensive approach proves
superior in controlling blood pressure and mitigating renal injury in Blacks who carry the
risk allele for LSD1 (rs587168). The findings of these investigations may lead to a new
approach in treating a subset (~30%) of the essential hypertension population (Black LSD1
risk allele hypertensives).