MK0954A-264 Filter Study (0954A-264)(COMPLETED)

• Status: Completed
• Trial end date: 2005-06-02
• Target enrollment: 0
• Participant gender: All

Summary

To compare the blood pressure lowering efficacy, safety and tolerability of a combination drug to a single drug taken once daily in patients with uncontrolled blood pressure following a 4-week filter on the single therapy product.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Merck Sharp & Dohme Corp.
• Treatments: Hydrochlorothiazide; Losartan

Criteria

Inclusion Criteria:

• Male and female patients with mild to severe hypertension (SiDBP 90-120 mmHg)

Exclusion Criteria:

• Systolic BP > 200 mmHg

• Secondary or malignant hypertension

• Taking more than 2 antihypertensive medications

• Hypertension induced by oral contraceptives

• Hx of cerebral vascular accident within 6 months

• Hx of angina, myocardial infarction, PCI, CABG, or decompensated CHF within 6 months

• Clinically significant AV conduction disturbance or potentially life threatening ventricular arrhythmias, valvular disease, cardiomyopathy, unexplained syncope

• History of angioedema

• Sensitivity to AII receptor antagonists or HCTZ, nephrotic syndrome,single kidney function

• Pregnancy or lactation.