Overview METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial) Status: Completed Trial end date: 2008-11-01 Target enrollment: Participant gender: Summary The aim of the study is to evaluate the efficacy of methotrexate to improve physical capacity in patients with symptomatic ischemic heart failure. Phase: Phase 2/Phase 3 Details Lead Sponsor: Instituto de Cardiologia do Rio Grande do SulTreatments: Folic AcidMethotrexateVitamin B Complex