MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)
Status:
Recruiting
Trial end date:
2026-07-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to find out if giving radiation therapy (RT) to areas of
metastatic prostate cancer at the time a participant is diagnosed will help control disease
better than the usual treatment. This treatment is called metastasis-directed radiotherapy
(MDRT).
The usual treatment for prostate cancer that has spread to other parts of the body is to give
lifelong treatment with hormone therapy (also known as androgen deprivation therapy or ADT).
Participants may also be given prostate RT even if the disease is metastatic. Participants
will receive hormone therapy (the standard treatment for prostate cancer) for 12 months. The
hormone therapy agents may be taken by mouth or given as an injection. Participants will also
have prostate RT. Up to 50 participants will have surgery to remove the prostate instead of
having prostate RT. A portion of the participants will be randomized to receive MDRT to areas
where the cancer has spread. For participants who have surgery to remove their prostate, they
will be asked to allow tissue samples collected during the surgery to be sent to an outside
lab for research tests and extra blood samples drawn for research tests before starting the
study, and at the time the cancer becomes worse if applicable. Participation in the study
will last approximately 12 months, and will be followed by their doctor for up to five years
per standard of care.
The main goal is to compare the efficacy of the standard of care (standard systemic therapy +
definitive prostate-directed local therapy) versus the standard of care with
metastasis-directed radiotherapy (MDRT) for consolidation of metastatic disease.