Luteal Phase Support With Estradiol In Poor Responders Undergoing In Vitro Fertilization

• Status: Unknown status
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The role of progesterone (P) supplementation in the luteal phase of in vitro fertilization (IVF) cycles is well established world-wide , but the influence of the luteal phase estradiol level on implantation is not clearly defined . There is a significant difference in estradiol levels between fertile and infertile cycles of fertile women who underwent donor insemination.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ain Shams University
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Polyestradiol phosphate

Criteria

Inclusion Criteria:

• Participants included in this study will have the following criteria : ( 2 of 3 criteria )

1. advanced maternal age or any other risk factor for POR :

1. Age ≥35 years

2. other risk factor of poor responder : ovarian surgery especially in case of endometrioma , chemotherapy, radiotherapy, autoimmune disorders, single ovary, chronic smoking, and unexplained Infertility.

2. previous poor ovarian response : Number of oocytes at the pickup time 3 or less .

3. Abnormal ovarian reserve tests :

1. FSH ≥12 mIu/ml in the early follicular phase .

2. Estradiol level more than 70 pg/dl in the early follicular phase

3. Anti-Mullerian hormone (AMH) below 0.5-1.1 ng/ml.

4. Antral follicle count (AFC) < 5-7 follicles .

Exclusion Criteria:

1. Age >35 with good ovarian response .

2. any intra-uterine pathology can affect receptivity , ( for example ; Sub-mucosal fibroid , intra-uterine adhesions ).

3. Severe male factor infertility.

4. Extended endometriosis (stage 3 or more) .

5. All contraindications for estradiol : venous thrombo-embolism , stroke and breast cancer