Overview

Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial)

Status:
Completed
Trial end date:
2015-09-01
Target enrollment:
Participant gender:
Summary
The broad, long-term objective of this research protocol is to improve the quality of life for patients suffering from lumbar spinal stenosis. This objective will be met by examining the safety and clinical efficacy of epidural steroid injections for treatment of pain associated with lumbar spinal stenosis. This prospective, randomized, double-blind controlled trial (RCT) will test the hypothesis that the effectiveness of epidural steroid injections (ESI) plus local anesthetic (LA) is greater than epidural injections of LA alone in older adults with lumbar spinal stenosis.
Phase:
Phase 4
Details
Lead Sponsor:
University of Washington
Collaborators:
Dallas VA Medical Center
Harvard Pilgrim Health Care
Harvard Vanguard Medical Associates
Henry Ford Hospital
Kaiser Permanente
Massachusetts General Hospital
Mayo Clinic
Oregon Health and Science University
Stanford University
University of California, San Francisco
University of Colorado, Denver
Virginia Spine Research Institute
Treatments:
Anesthetics
Anesthetics, Local
BB 1101
Betamethasone
Betamethasone benzoate
Betamethasone sodium phosphate
Betamethasone Valerate
Betamethasone-17,21-dipropionate
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Lidocaine
Methylprednisolone
Methylprednisolone Acetate
Methylprednisolone Hemisuccinate
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Triamcinolone
Triamcinolone Acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide