Overview

Loxapine and Weaning From Ventilator

Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
0
Participant gender:
All
Summary
Patients may be very agitated during the weaning period from mechanical ventilation. Administration of loxapine, a neuroleptic that does not notably affect ventilatory drive, may help in obtaining an adequate level of cooperation and, therefore, in reducing the duration of mechanical ventilation.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Treatments:
Loxapine
Criteria
Inclusion Criteria:

- Patients who are eligible for weaning from the respirator (FIO2 less than 50%;
positive end expiratory pressure [PEEP] level less than 6 cmH2O)

- Patients whose agitation (according to accepted scores) during a weaning trial
precludes extubation

Exclusion Criteria:

- History of convulsions or epilepsy