Recently there was described an increase in left ventricular mass after kidney donation. It
is uncertain whether this is reversible or not. Allopurinol lowers uric acid in the blood and
is normally indicated for gout, but studies have showed that it also can reduce the thickness
of the left ventricle of the heart in people with heart- and kidney disease.
The investigators wish to give allopurinol or placebo to kidney donors based on randomization
and investigate if this has the same effect on kidney donors. The investigators are assessing
this by performing a cardiac MRI at baseline and after 9 months of treatment. In addition the
investigators wish to see if allopurinol can have beneficial effects on blood pressure and
insulin sensitivity as well.
Phase:
Phase 2
Details
Lead Sponsor:
Oslo University Hospital
Collaborators:
South-Eastern Norway Regional Health Authority University of Oslo