Lower Third Molar Removal With 2% and 4% Articaine
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The present clinical trial randomized compared the clinical efficacy of the local anesthetics
articaine in two concentrations, 2% and 4%, in association with 1:200,000 adrenaline, for the
removal of lower third molars. Onset, duration of postoperative analgesia, duration of
anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters,
postoperative mouth opening and wound healing at the 7th postoperative day were evaluated.
For this purpose, 50 healthy volunteers underwent removal of symmetrically positioned lower
third molars, in two separate appointments (one to two months apart), under local anesthesia
with either articaine 2% or 4% (both with 1:200,000 adrenaline) in a double-blind, randomized
and crossed manner.
Phase:
Phase 4
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo