Interstitial cystitis/Bladder Pain Syndrome (IC/PBS) is a constellation of symptoms of pelvic
discomfort that includes both bladder-related pain as well as urinary frequency, urgency, and
nocturia in the absence of an identifiable etiology that affects likely more than 5.4 million
patients in the United States. There is a significant overlap in patients with IC/PBS and
those with fibromyalgia and chronic pelvic pain syndrome. Low-dose naltrexone (LDN) has been
shown to be effective for the treatment of chronic pain conditions.
The primary aim of this study is to evaluate if LDN improves pain scores and lower urinary
tract symptoms in patients with IC/PBS. A secondary aim is to show that it has a low adverse
event profile.