Low-dose Hydrocortisone in Acutely Burned Patients
Status:
Completed
Trial end date:
2010-10-01
Target enrollment:
Participant gender:
Summary
Major burns trigger the release of circulating mediators, as cytokines and endotoxin that
induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to
those seen in septic shock. After the initial hypovolemic phase, patients with extensive
burns often present a shock with increased cardiac output and reduced systemic vascular
resistances. As described in septic shock, we test the hypothesis that low-dose
hydrocortisone could decrease the duration of the shock period.