Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART

• Status: Terminated
• Trial end date: 2019-04-30
• Target enrollment: 0
• Participant gender: Female

Summary

The objective of this prospective randomized clinical trial is to investigate whether the addition of low-dose hCG to a short GnRH-agonist protocol for IVF and ovarian stimulation with rFSH from the onset of the follicular phase and throughout stimulation in sub fertile women undergoing IVF, improves pregnancy rates.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National and Kapodistrian University of Athens
• Collaborators: Aristotle University Of Thessaloniki; University of Thessaly
• Treatments: Chorionic Gonadotropin; Deslorelin

Criteria

Inclusion Criteria:

1. Age: between 35 and 40 years of age,

2. Physiological menstrual cycles (24-35 day cycle),

3. Normal endocrine function (normal PRL and TSH, FSH ≤ 15 IU / ml),

4. Transvaginal ultrasound (TVS) without pathological findings,

5. Free personal medical history,

6. Indication for IVF / ICSI (NICE, 2016)

7. 1st or 2nd IVF / ICSI cycle

Exclusion Criteria:

1. Endocrine or metabolic disorders, e.g. PCO (S)

2. Pathology of the uterus and / or endometrium,

3. Pelvic inflammatory disease (PID),

4. Basal FSH levels> 15 IU / ml,

5. Surgery in the ovaries,

6. Body Mass Index (BMI) ≥ 35 kg / m2,

7. Age: <35 years &> 41 years old