Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients

• Status: Unknown status
• Trial end date: 2021-04-30
• Target enrollment: 0
• Participant gender: All

Summary

For patients undergoing mechanical ventilation, light sedation is better than deep sedation for the outcomes, which is manifested as shortened length of ICU stay, shortened duration of mechanical ventilation, and decreased mortality. In a recent study of the investigators, low-dose dexmedetomidine without sedative effects (0.1 ug/kg/h) improved sleep quality and reduced the incidence of delirium in elderly patients admitted to the ICU after surgery. The investigators hypothesize that, for ICU patients with prolonged mechanical ventilation, low-dose dexmedetomidine infusion (0.1 ug/kg/h) may also be effective in decreasing delirium. The purpose of this study is to investigate whether low-dose dexmedetomidine infusion can reduce the incidence of delirium in ICU patients with prolonged duration of mechanical ventilation (>= 24 hours).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University First Hospital
• Collaborator: Peking University Third Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• aged 18 years or older;

• admitted to the ICU;

• with expected duration of mechanical ventilation of more than 24 hours.

Exclusion Criteria:

• refused to participate;

• aged less than 18 years;

• pregnant;

• preoperative history of schizophrenia, epilepsy, Parkinsonism, or myasthenia gravis;

• inability to communicate in the preoperative period (coma, profound dementia, or language barrier);

• brain injury or neurosurgery;

• known preoperative left ventricular ejection fraction less than 30%, sick sinus syndrome, severe sinus bradycardia (<50 beats per min [bpm]), or second degree or greater atrioventricular block without pacemaker;

• severe hepatic dysfunction (Child-Pugh class C);

• severe renal dysfunction (undergoing dialysis before surgery);

• less likely to survive for more than 24 hours.