COIN trial is a a prospective, randomized, placebo-controlled, double-blind, multicenter
clinical study. Approximately 230 patients with small abdominal aortic aneurysms (AAA) will
be randomly allocated to low-dose colchicine group or placebo group. All study patients will
be followed up in the outpatient clinic every 3 months and undergo CTA scans after 24 months
from randomization. The primary objective is to test the hypothesis that low dose colchicine
can inhibit the progression of AAA diameter. The secondary objective is to test the
hypothesis that low dose colchicine can inhibit the progression of AAA volume, reduce the
incidence of clinical outcomes associated with AAA, reduce the incidence of major adverse
cardiovascular events and all-cause mortality.
Phase:
N/A
Details
Lead Sponsor:
Guangdong Provincial People's Hospital
Collaborators:
Peking Union Medical College Hospital Peking University Shougang Hospital Shenzhen Bao an People's Hospital Shenzhen People's Hospital The First Affiliated Hospital of Guangzhou Medical University The Second Xianya Hospital of Central South University Zhongshan People's Hospital, Guangdong, China